Subnanogram proteomics: impact of LC column selection, MS instrumentation and data analysis strategy on proteome coverage for trace samples

One of the greatest challenges for mass spectrometry (MS)-based proteomics is the limited ability to analyze small samples. Here we investigate the relative contributions of liquid chromatography (LC), MS instrumentation and data analysis methods with the aim of improving proteome coverage for sampl...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Int J Mass Spectrom
Main Authors: Zhu, Ying, Zhao, Rui, Piehowski, Paul D., Moore, Ronald J., Lim, Sujung, Orphan, Victoria J., Paša-Tolić, Ljiljana, Qian, Wei-Jun, Smith, Richard D., Kelly, Ryan T.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863755/
https://ncbi.nlm.nih.gov/pubmed/29576737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2017.08.016
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