Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling

Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in part, to be induced by phosphate imbalance. T...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Willems, Brecht A., Furmanik, Malgorzata, Caron, Marjolein M. J., Chatrou, Martijn L. L., Kusters, Dennis H. M., Welting, Tim J. M., Stock, Michael, Rafael, Marta S., Viegas, Carla S. B., Simes, Dina C., Vermeer, Cees, Reutelingsperger, Chris P. M., Schurgers, Leon J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862840/
https://ncbi.nlm.nih.gov/pubmed/29563538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23353-y
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