Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a powerful lung carcinogen in animal models and is considered a causative factor for lung cancer in people who use tobacco products. NNK undergoes metabolic activation—a critical step in its mechanism of carcino...

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Publicado en:Carcinogenesis
Main Authors: Ma, Bin, Zarth, Adam T, Carlson, Erik S, Villalta, Peter W, Upadhyaya, Pramod, Stepanov, Irina, Hecht, Stephen S
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Carcinogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862267/
https://ncbi.nlm.nih.gov/pubmed/29194532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx135
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