Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus

Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD) genes rather than to knock them out (KO). Here we report on the implications of genetic KO versus MO-mediated KD of the mesoderm-specifying Brachyury paralogs in the frog Xe...

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Bibliografske podrobnosti
izdano v:Dev Cell
Main Authors: Gentsch, George E., Spruce, Thomas, Monteiro, Rita S., Owens, Nick D.L., Martin, Stephen R., Smith, James C.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861998/
https://ncbi.nlm.nih.gov/pubmed/29478923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.01.022
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