Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus

Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD) genes rather than to knock them out (KO). Here we report on the implications of genetic KO versus MO-mediated KD of the mesoderm-specifying Brachyury paralogs in the frog Xe...

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Vydáno v:Dev Cell
Hlavní autoři: Gentsch, George E., Spruce, Thomas, Monteiro, Rita S., Owens, Nick D.L., Martin, Stephen R., Smith, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861998/
https://ncbi.nlm.nih.gov/pubmed/29478923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.01.022
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