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Morpholinos do not elicit an innate immune response during early Xenopus embryogenesis

Gentsch et al. (2018) recently reported that a common side effect of translation-blocking morpholino antisense oligonucleotides is the induction of a set of innate immune response genes in Xenopus embryos, and that splicing-blocking morpholinos lead to unexpected off-target mis-splicing events. Here...

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Publicat a:Dev Cell
Autors principals: Paraiso, Kitt D., Blitz, Ira L., Zhou, Jeff J., Cho, Ken W.Y.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599594/
https://ncbi.nlm.nih.gov/pubmed/31112700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.019
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