Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus

Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD) genes rather than to knock them out (KO). Here we report on the implications of genetic KO versus MO-mediated KD of the mesoderm-specifying Brachyury paralogs in the frog Xe...

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Gepubliceerd in:Dev Cell
Hoofdauteurs: Gentsch, George E., Spruce, Thomas, Monteiro, Rita S., Owens, Nick D.L., Martin, Stephen R., Smith, James C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861998/
https://ncbi.nlm.nih.gov/pubmed/29478923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.01.022
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