A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

The RNA helicase UPF1 is a key component of the nonsense mediated mRNA decay (NMD) pathway. Previous X-ray crystal structures of UPF1 elucidated the molecular mechanisms of its catalytic activity and regulation. In this study, we examine features of the UPF1 core and identify a structural element th...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Gowravaram, Manjeera, Bonneau, Fabien, Kanaan, Joanne, Maciej, Vincent D, Fiorini, Francesca, Raj, Saurabh, Croquette, Vincent, Le Hir, Hervé, Chakrabarti, Sutapa
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861435/
https://ncbi.nlm.nih.gov/pubmed/29378013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky040
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