HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

Up-Frameshift Suppressor 1 Homolog (UPF1) is a key factor for nonsense-mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs. Here, we study NMD inhibition during infection by human T-cell lymphotropic virus type I (HTLV-1) and characterise the influence of the retroviral Tax...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Fiorini, Francesca, Robin, Jean-Philippe, Kanaan, Joanne, Borowiak, Malgorzata, Croquette, Vincent, Le Hir, Hervé, Jalinot, Pierre, Mocquet, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789848/
https://ncbi.nlm.nih.gov/pubmed/29382845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02793-6
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