Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues. Partially modified siRNAs (up to 70% of the nucleotides) provide significant stabilization in vitro and are commercially avai...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Davis, Sarah M, Morrissey, David V, Zamore, Phillip D, Karumanchi, S Ananth, Moore, Melissa J, Aronin, Neil, Khvorova, Anastasia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Chemical Biology and Nucleic Acid Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861422/
https://ncbi.nlm.nih.gov/pubmed/29432571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky037
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