Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance

While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovascular diseases. However, the deleterious effects of long-te...

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Publicat a:Cell Rep
Autors principals: Price, Nathan L., Singh, Abhishek K., Rotllan, Noemi, Goedeke, Leigh, Wing, Allison, Canfrán-Duque, Alberto, Diaz-Ruiz, Alberto, Araldi, Elisa, Baldán, Ángel, Camporez, Joao-Paulo, Suárez, Yajaira, Rodeheffer, Matthew S., Shulman, Gerald I., de Cabo, Rafael, Fernández-Hernando, Carlos
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860817/
https://ncbi.nlm.nih.gov/pubmed/29466739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.074
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