Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis

miR-33 is an intronic microRNA within the gene encoding the SREBP2 transcription factor. Like its host gene, miR-33 has been shown to be an important regulator of lipid metabolism. Inhibition of miR-33 has been shown to promote cholesterol efflux in macrophages by targeting the cholesterol transport...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Price, Nathan L., Zhang, Xinbo, Fernández-Tussy, Pablo, Singh, Abhishek K., Burnap, Sean A., Rotllan, Noemi, Goedeke, Leigh, Sun, Jonathan, Canfrán-Duque, Alberto, Aryal, Binod, Mayr, Manuel, Suárez, Yajaira, Fernández-Hernando, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865172/
https://ncbi.nlm.nih.gov/pubmed/33495342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006478118
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