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Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr(−/−) mice

OBJECTIVE: To study the efficacy of anti-miRNA-33 therapy on the progression of atherosclerosis. APPROACH AND RESULTS: Ldlr(−/−) mice were injected subcutaneously with PBS, control or anti-miR-33 oligonucleotides weekly and fed a Western diet for 12 weeks. At the end of treatment, the expression of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rotllan, Noemi, Ramírez, Cristina M., Aryal, Binod, Esau, Christine C., Fernández-Hernando, Carlos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157595/
https://ncbi.nlm.nih.gov/pubmed/23702658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301732
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