CRISPR RNA-dependent binding and cleavage of endogenous RNAs by the Campylobacter jejuni Cas9

Cas9 nucleases naturally utilize CRISPR RNAs (crRNAs) to silence foreign double-stranded DNA. While recent work has shown that some Cas9 nucleases can also target RNA, RNA recognition has required nuclease modifications or accessory factors. Here, we show that the Campylobacter jejuni Cas9 (CjCas9)...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Dugar, Gaurav, Leenay, Ryan T., Eisenbart, Sara K., Bischler, Thorsten, Aul, Belinda U., Beisel, Chase L., Sharma, Cynthia M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859949/
https://ncbi.nlm.nih.gov/pubmed/29499139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.032
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