CRISPR RNA-dependent binding and cleavage of endogenous RNAs by the Campylobacter jejuni Cas9

Cas9 nucleases naturally utilize CRISPR RNAs (crRNAs) to silence foreign double-stranded DNA. While recent work has shown that some Cas9 nucleases can also target RNA, RNA recognition has required nuclease modifications or accessory factors. Here, we show that the Campylobacter jejuni Cas9 (CjCas9)...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Dugar, Gaurav, Leenay, Ryan T., Eisenbart, Sara K., Bischler, Thorsten, Aul, Belinda U., Beisel, Chase L., Sharma, Cynthia M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859949/
https://ncbi.nlm.nih.gov/pubmed/29499139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.032
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