CRISPR RNA-dependent binding and cleavage of endogenous RNAs by the Campylobacter jejuni Cas9

Cas9 nucleases naturally utilize CRISPR RNAs (crRNAs) to silence foreign double-stranded DNA. While recent work has shown that some Cas9 nucleases can also target RNA, RNA recognition has required nuclease modifications or accessory factors. Here, we show that the Campylobacter jejuni Cas9 (CjCas9)...

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Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Dugar, Gaurav, Leenay, Ryan T., Eisenbart, Sara K., Bischler, Thorsten, Aul, Belinda U., Beisel, Chase L., Sharma, Cynthia M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859949/
https://ncbi.nlm.nih.gov/pubmed/29499139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.032
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