Prevention of Protein Kinase G-1α Oxidation Suppresses Anti-Hypertrophic/Anti-fibrotic Effects from PDE5 Inhibition but not sGC Stimulation

BACKGROUND: Stimulation of soluble guanylate cyclase (sGC) or inhibition of phosphodiesterase type-5 (PDE5) activates protein kinase G-1α (PKG1α) to counteract cardiac hypertrophy and failure. PKG1α acts within localized intracellular domains; however, its oxidation at cysteine-42, linking homo-mono...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Circ Heart Fail
Hoofdauteurs: Nakamura, Taishi, Zhu, Guangshuo, Ranek, Mark J., Kokkonen-Simon, Kristen, Zhang, Manling, Kim, Grace E., Tsujita, Kenichi, Kass, David A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858464/
https://ncbi.nlm.nih.gov/pubmed/29545395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004740
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items