sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH

Endothelial dysfunction and reduced nitric oxide (NO) signaling are a key element of the pathophysiology of nonalcoholic steatohepatitis (NASH). Stimulators of soluble guanylate cyclase (sGC) enhance NO signaling; have been shown preclinically to reduce inflammation, fibrosis, and steatosis; and thu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561202/
https://ncbi.nlm.nih.gov/pubmed/31085647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821045116
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