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Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform

CoA is the major acyl carrier in mammals and a key cofactor in energy metabolism. Dynamic regulation of CoA in different tissues and organs supports metabolic flexibility. Two mammalian Nudix hydrolases, Nudt19 and Nudt7, degrade CoA in vitro. Nudt19 and Nudt7 possess conserved Nudix and CoA signatu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shumar, Stephanie A., Kerr, Evan W., Geldenhuys, Werner J., Montgomery, Grace E., Fagone, Paolo, Thirawatananond, Puchong, Saavedra, Harry, Gabelli, Sandra B., Leonardi, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857999/
https://ncbi.nlm.nih.gov/pubmed/29378847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001358
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