Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform

CoA is the major acyl carrier in mammals and a key cofactor in energy metabolism. Dynamic regulation of CoA in different tissues and organs supports metabolic flexibility. Two mammalian Nudix hydrolases, Nudt19 and Nudt7, degrade CoA in vitro. Nudt19 and Nudt7 possess conserved Nudix and CoA signatu...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Shumar, Stephanie A., Kerr, Evan W., Geldenhuys, Werner J., Montgomery, Grace E., Fagone, Paolo, Thirawatananond, Puchong, Saavedra, Harry, Gabelli, Sandra B., Leonardi, Roberta
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Metabolism
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857999/
https://ncbi.nlm.nih.gov/pubmed/29378847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001358
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