Protein arginine methyltransferase 7–mediated microRNA-221 repression maintains Oct4, Nanog, and Sox2 levels in mouse embryonic stem cells

The stemness maintenance of embryonic stem cells (ESCs) requires pluripotency transcription factors, including Oct4, Nanog, and Sox2. We have previously reported that protein arginine methyltransferase 7 (PRMT7), an epigenetic modifier, is an essential pluripotency factor that maintains the stemness...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Chen, Tsai-Yu, Lee, Sung-Hun, Dhar, Shilpa S., Lee, Min Gyu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857983/
https://ncbi.nlm.nih.gov/pubmed/29378844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000425
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