SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2

Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog is strictly regulated by Oct4/Sox2 heter...

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Autores principales: Wu, Yongyan, Guo, Zekun, Wu, Haibo, Wang, Xiaohai, Yang, Lixia, Shi, Xiaoyan, Du, Juan, Tang, Bo, Li, Wenzhong, Yang, Liping, Zhang, Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382131/
https://ncbi.nlm.nih.gov/pubmed/22745796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039606
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