SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2

Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog is strictly regulated by Oct4/Sox2 heter...

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Bibliographic Details
Main Authors:	Wu, Yongyan, Guo, Zekun, Wu, Haibo, Wang, Xiaohai, Yang, Lixia, Shi, Xiaoyan, Du, Juan, Tang, Bo, Li, Wenzhong, Yang, Liping, Zhang, Yong
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2012
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3382131/ https://ncbi.nlm.nih.gov/pubmed/22745796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039606
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SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2

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