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SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2
Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog is strictly regulated by Oct4/Sox2 heter...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382131/ https://ncbi.nlm.nih.gov/pubmed/22745796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039606 |
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