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Ethanol Alters the Balance of Sox2, Oct4, and Nanog Expression in Distinct Subpopulations During Differentiation of Embryonic Stem Cells

The transcription factors Sox2, Oct4, and Nanog regulate within a narrow dose-range embryonic stem (ES) cell pluripotency and cell lineage commitment. Excess of Oct4 relative to Sox2 guides cells to mesoendoderm (ME), while abundance of Sox2 promotes neuroectoderm (NE) formation. Literature does not...

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Bibliografiske detaljer
Main Authors: Ogony, Joshua W., Malahias, Evangelia, Vadigepalli, Rajanikanth, Anni, Helen
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715797/
https://ncbi.nlm.nih.gov/pubmed/23470161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2012.0513
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