Ethanol Diverts Early Neuronal Differentiation Trajectory of Embryonic Stem Cells by Disrupting the Balance of Lineage Specifiers

BACKGROUND: Ethanol is a toxin responsible for the neurodevelopmental deficits of Fetal Alcohol Spectrum Disorders (FASD). Recent evidence suggests that ethanol modulates the protein expression of lineage specifier transcription factors Oct4 (Pou5f1) and Sox2 in early stages of mouse embryonic stem...

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Autores principales: Sánchez-Alvarez, Rosa, Gayen, Saurabh, Vadigepalli, Rajanikanth, Anni, Helen
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665827/
https://ncbi.nlm.nih.gov/pubmed/23724002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063794
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