Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

Perturbations in stress granule (SG) dynamics may be at the core of amyotrophic lateral sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in human motor neurons has been challenging, thus hindering the identification of effective therapeutics. Here, we report the gene...

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Publicado en:Stem Cell Reports
Main Authors: Marrone, Lara, Poser, Ina, Casci, Ian, Japtok, Julia, Reinhardt, Peter, Janosch, Antje, Andree, Cordula, Lee, Hyun O., Moebius, Claudia, Koerner, Ellen, Reinhardt, Lydia, Cicardi, Maria Elena, Hackmann, Karl, Klink, Barbara, Poletti, Angelo, Alberti, Simon, Bickle, Marc, Hermann, Andreas, Pandey, Udai Bhan, Hyman, Anthony A., Sterneckert, Jared L.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857889/
https://ncbi.nlm.nih.gov/pubmed/29358088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.12.018
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