PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells

The spindle assembly checkpoint (SAC) acts as a molecular safeguard in ensuring faithful chromosome transmission during mitosis, which is regulated by a complex interplay between phosphatases and kinases including PLK1. Adenomatous polyposis coli (APC) germline mutations cause aneuploidy and are res...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Raab, Monika, Sanhaji, Mourad, Matthess, Yves, Hörlin, Albrecht, Lorenz, Ioana, Dötsch, Christina, Habbe, Nils, Waidmann, Oliver, Kurunci-Csacsko, Elisabeth, Firestein, Ron, Becker, Sven, Strebhardt, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856809/
https://ncbi.nlm.nih.gov/pubmed/29549256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03494-4
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