Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8

Upon interaction of the CD95 receptor with its ligand, sequential association of the adaptor molecule FADD (MORT1), pro-forms of caspases-8/10, and the caspase-8/10 regulator c-FLIP leads to the formation of a death-inducing signaling complex. Here, we identify polo-like kinase (Plk) 3 as a new inte...

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Bibliografiske detaljer
Udgivet i:Cell Res
Main Authors: Helmke, Christina, Raab, Monika, Rödel, Franz, Matthess, Yves, Oellerich, Thomas, Mandal, Ranadip, Sanhaji, Mourad, Urlaub, Henning, Rödel, Claus, Becker, Sven, Strebhardt, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973331/
https://ncbi.nlm.nih.gov/pubmed/27325299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.78
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