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pERK 1/2 inhibit Caspase‐8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner

ERK 1/2 are found to be hyperactive in many cancers. Active ERK 1/2 (pERK 1/2) are known to protect cancer cells from undergoing death receptor‐mediated apoptosis, although the mechanism(s) behind this is poorly understood. Through in vitro kinase assays and mass‐spectrometry we demonstrate that pER...

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Publicat a:Mol Oncol
Autors principals: Mandal, Ranadip, Raab, Monika, Matthess, Yves, Becker, Sven, Knecht, Rainald, Strebhardt, Klaus
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528548/
https://ncbi.nlm.nih.gov/pubmed/24342355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.11.003
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