Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

Antiangiogenic agents block the effects of tumor-derived angiogenic factors (paracrine factors), such as vascular endothelial growth factor (VEGF), on endothelial cells (EC), inhibiting the growth of solid tumors. However, whether inhibition of angiogenesis also may play a role in liquid tumors is n...

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Hlavní autoři: Dias, Sergio, Hattori, Koichi, Heissig, Beate, Zhu, Zhenping, Wu, Yan, Witte, Larry, Hicklin, Daniel J., Tateno, Masatoshi, Bohlen, Peter, Moore, Malcolm A. S., Rafii, Shahin
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC58564/
https://ncbi.nlm.nih.gov/pubmed/11553814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191117498
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