Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment

The mechanism by which angiogenic factors recruit bone marrow (BM)-derived quiescent endothelial and hematopoietic stem cells (HSCs) is not known. Here, we report that functional vascular endothelial growth factor receptor-1 (VEGFR1) is expressed on human CD34(+) and mouse Lin(−)Sca-1(+)c-Kit(+) BM-...

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Detalhes bibliográficos
Main Authors: Hattori, Koichi, Heissig, Beate, Wu, Yan, Dias, Sergio, Tejada, Rafael, Ferris, Barbara, Hicklin, Daniel J., Zhu, Zhenping, Bohlen, Peter, Witte, Larry, Hendrikx, Jan, Hackett, Neil R., Crystal, Ronald G., Moore, Malcolm A.S., Werb, Zena, Lyden, David, Rafii, Shahin
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779715/
https://ncbi.nlm.nih.gov/pubmed/12091880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm740
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