Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2 mediated regeneration of sinusoidal endothelial cells

The phenotypic attributes and molecular determinants for the regeneration of bone marrow (BM) sinusoidal endothelial cells (SECs) and their contribution to hematopoiesis are unknown. We show that after myelosuppression VEGFR2 activation promotes reassembly of regressed SECs, reconstituting hematopoi...

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Detalhes bibliográficos
Main Authors: Hooper, Andrea T., Butler, Jason M., Nolan, Daniel J, Kranz, Andrea, Iida, Kaoruko, Kobayashi, Mariko, Kopp, Hans-Georg, Shido, Koji, Petit, Isabelle, Yanger, Kilangsungla, James, Daylon, Witte, Larry, Zhu, Zhenping, Wu, Yan, Pytowski, Bronislaw, Rosenwaks, Zev, Mittal, Vivek, Sato, Thomas N., Rafii, Shahin
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228275/
https://ncbi.nlm.nih.gov/pubmed/19265665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.01.006
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