VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling

VEGF-A and the VEGF receptors are critical for regulating angiogenesis during development, homeostasis and in pathological conditions, such as cancer and proliferative retinopathies. Most effects of VEGF-A are mediated by the VEGFR2 and its co-receptor, Neuropilin-1 (NRP-1). Here, we show that VEGFR...

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Main Authors: Swendeman, Steven, Mendelson, Karen, Weskamp, Gisela, Horiuchi, Keisuke, Deutsch, Urban, Scherle, Peggy, Hooper, Andrea, Rafii, Shahin, Blobel, Carl P
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574836/
https://ncbi.nlm.nih.gov/pubmed/18818406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.184416
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