Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals. Matrix metalloproteinase-9 (MMP-9), induced in BM cells, releases soluble Kit-ligand (sKitL), permitting the transfer of endothelial and hemato...

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Main Authors: Heissig, Beate, Hattori, Koichi, Dias, Sergio, Friedrich, Matthias, Ferris, Barbara, Hackett, Neil R., Crystal, Ronald G., Besmer, Peter, Lyden, David, Moore, Malcolm A.S., Werb, Zena, Rafii, Shahin
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826110/
https://ncbi.nlm.nih.gov/pubmed/12062105
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