The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

Many chemotherapeutic agents induce mitochondrial-membrane disruption to initiate apoptosis. However, the upstream events leading to drug-induced mitochondrial perturbation have remained poorly defined. We have used a variety of physiological and pharmacological inhibitors of distinct apoptotic path...

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Main Authors: Ruefli, Astrid A., Ausserlechner, Michael J., Bernhard, David, Sutton, Vivien R., Tainton, Kellie M., Kofler, Reinhard, Smyth, Mark J., Johnstone, Ricky W.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2001
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC58560/
https://ncbi.nlm.nih.gov/pubmed/11535817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191208598
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