Interactions, localization, and phosphorylation of the m(6)A generating METTL3–METTL14–WTAP complex

N(6)-methyladenine (m(6)A) is found on many eukaryotic RNAs including mRNAs. m(6)A modification has been implicated in mRNA stability and turnover, localization, or translation efficiency. A heterodimeric enzyme complex composed of METTL3 and METTL14 generates m(6)A on mRNAs. METTL3/14 is found in t...

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Publicado en:RNA
Autores principales: Schöller, Eva, Weichmann, Franziska, Treiber, Thomas, Ringle, Sam, Treiber, Nora, Flatley, Andrew, Feederle, Regina, Bruckmann, Astrid, Meister, Gunter
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855951/
https://ncbi.nlm.nih.gov/pubmed/29348140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064063.117
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