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Interactions, localization, and phosphorylation of the m(6)A generating METTL3–METTL14–WTAP complex
N(6)-methyladenine (m(6)A) is found on many eukaryotic RNAs including mRNAs. m(6)A modification has been implicated in mRNA stability and turnover, localization, or translation efficiency. A heterodimeric enzyme complex composed of METTL3 and METTL14 generates m(6)A on mRNAs. METTL3/14 is found in t...
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| Udgivet i: | RNA |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5855951/ https://ncbi.nlm.nih.gov/pubmed/29348140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064063.117 |
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