Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics

A key feature of Notch signaling is that it directs immediate changes in transcription via the DNA-binding factor CSL, switching it from repression to activation. How Notch generates both a sensitive and accurate response—in the absence of any amplification step—remains to be elucidated. To address...

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Publicado no:Dev Cell
Main Authors: Gomez-Lamarca, Maria J., Falo-Sanjuan, Julia, Stojnic, Robert, Abdul Rehman, Sohaib, Muresan, Leila, Jones, Matthew L., Pillidge, Zoe, Cerda-Moya, Gustavo, Yuan, Zhenyu, Baloul, Sarah, Valenti, Phillippe, Bystricky, Kerstin, Payre, Francois, O'Holleran, Kevin, Kovall, Rhett, Bray, Sarah J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855320/
https://ncbi.nlm.nih.gov/pubmed/29478922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.01.020
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