Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide

Ozone and obesity both increase IL-17A in the lungs. In mice, obesity augments the airway hyperresponsiveness and neutrophil recruitment induced by acute ozone exposure. Therefore, we examined the role of IL-17A in obesity-related increases in the response to ozone observed in obese mice. Lean wild-...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Mathews, Joel A., Krishnamoorthy, Nandini, Kasahara, David I., Hutchinson, John, Cho, Youngji, Brand, Jeffrey D., Williams, Alison S., Wurmbrand, Allison P., Ribeiro, Luiza, Cuttitta, Frank, Sunday, Mary E., Levy, Bruce D., Shore, Stephanie A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854955/
https://ncbi.nlm.nih.gov/pubmed/28957638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0071OC
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