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Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant
A key antioxidant pathway, the Keap1-Nrf2 system, is regulated by p62/Sqstm1 via multiple mechanisms, including gene expression, posttranslational modifications (such as ubiquitination and phosphorylation), and autophagic degradation of p62/Sqstm1 and Keap1. Here we demonstrate a novel mode of regul...
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| Publicado en: | Mol Cell Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5854834/ https://ncbi.nlm.nih.gov/pubmed/29339380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00642-17 |
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