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Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

The understanding of protein evolution depends on the ability to relate the impact of mutations on molecular traits to organismal fitness. Biological activity and robustness have been regarded as important features in shaping protein evolutionary landscapes. Conformational dynamics, which is essenti...

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Bibliographic Details
Published in:Mol Biol Evol
Main Authors: González, Mariano M., Abriata, Luciano A., Tomatis, Pablo E., Vila, Alejandro J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854100/
https://ncbi.nlm.nih.gov/pubmed/26983555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw052
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