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Flexibility and design - conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin
Although protein design has been used to introduce new functions, designed variants generally only function as well as natural proteins after rounds of laboratory evolution. One possibility for this pattern is that designed mutants frequently sample nonfunctional conformations. To test this idea, we...
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| Udgivet i: | Structure |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5415430/ https://ncbi.nlm.nih.gov/pubmed/28416112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.03.009 |
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