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Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury
Transforming growth factor-β1 (TGF-β1) signaling in hepatic stellate cells (HSCs) plays a primary role in liver fibrosis, but the source of TGF-β1 is unclear. Because platelets are rich in TGF-β1, we examined the role of platelet TGF-β1 in liver fibrosis by challenging wild-type (WT) mice and mice d...
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851416/ https://ncbi.nlm.nih.gov/pubmed/29490978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010868 |
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