HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: role of platelet-derived TGF-β1 and intervention via anti-oxidant pathways

OBJECTIVE: Chronic kidney disease (CKD) with tubular injury and fibrosis occurs in HIV infection treated with certain protease inhibitor (PI)-based antiretroviral therapies. The pathophysiology is unclear. DESIGN: We hypothesized that fibrosis, mediated by platelet-derived transforming growth factor...

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Veröffentlicht in:AIDS
Hauptverfasser: Laurence, Jeffrey, Elhadad, Sonia, Gostynska, Sandra, Yu, Zhongxin, Terry, Hunter, Varshney, Rohan, Fung, Kar-Ming, Choi, Mary E., Ahamed, Jasimuddin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210074/
https://ncbi.nlm.nih.gov/pubmed/32167970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002516
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