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Inactivation of platelet-derived TGF-β1 attenuates aortic stenosis progression in a robust murine model
Aortic stenosis (AS) is a degenerative heart condition characterized by fibrosis and narrowing of aortic valves (AV), resulting in high wall shear stress (WSS) across valves. AS is associated with high plasma levels of transforming growth factor-β1 (TGF-β1), which can be activated by WSS to induce o...
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6418501/ https://ncbi.nlm.nih.gov/pubmed/30846427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018025817 |
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