Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis

BACKGROUND: Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which...

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Detaylı Bibliyografya
Yayımlandı:J Am Heart Assoc
Asıl Yazarlar: Budatha, Madhusudhan, Zhang, Jiasheng, Zhuang, Zhen W., Yun, Sanguk, Dahlman, James E., Anderson, Daniel G., Schwartz, Martin A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850249/
https://ncbi.nlm.nih.gov/pubmed/29382667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007501
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