Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis

Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin α5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Yun, Sanguk, Hu, Rui, Schwaemmle, Melanie E., Scherer, Alexander N., Zhuang, Zhenwu, Koleske, Anthony J., Pallas, David C., Schwartz, Martin A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819111/
https://ncbi.nlm.nih.gov/pubmed/31408443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127692
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