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Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis

Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin α5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Yun, Sanguk, Hu, Rui, Schwaemmle, Melanie E., Scherer, Alexander N., Zhuang, Zhenwu, Koleske, Anthony J., Pallas, David C., Schwartz, Martin A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819111/
https://ncbi.nlm.nih.gov/pubmed/31408443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127692
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