Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis

BACKGROUND: Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Budatha, Madhusudhan, Zhang, Jiasheng, Zhuang, Zhen W., Yun, Sanguk, Dahlman, James E., Anderson, Daniel G., Schwartz, Martin A.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850249/
https://ncbi.nlm.nih.gov/pubmed/29382667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007501
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