Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis

BACKGROUND: Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Heart Assoc
Auteurs principaux: Budatha, Madhusudhan, Zhang, Jiasheng, Zhuang, Zhen W., Yun, Sanguk, Dahlman, James E., Anderson, Daniel G., Schwartz, Martin A.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850249/
https://ncbi.nlm.nih.gov/pubmed/29382667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007501
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