The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100

Arginine is a semi‐essential amino acid that plays a key role in cell survival and proliferation in normal and malignant cells. BCT‐100, a pegylated (PEG) recombinant human arginase, can deplete arginine and starve malignant cells of the amino acid. Acute lymphoblastic leukemia (ALL) is the most com...

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Udgivet i:Int J Cancer
Main Authors: De Santo, Carmela, Booth, Sarah, Vardon, Ashley, Cousins, Antony, Tubb, Vanessa, Perry, Tracey, Noyvert, Boris, Beggs, Andrew, Ng, Margaret, Halsey, Christina, Kearns, Pamela, Cheng, Paul, Mussai, Francis
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Cancer Therapy and Prevention
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849425/
https://ncbi.nlm.nih.gov/pubmed/29168171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31170
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