Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

BACKGROUND: Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 antibodies to stimulate anti-cancer T cell responses, y...

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Bibliographic Details
Published in:J Hematol Oncol
Main Authors: De Santo, Carmela, Cheng, Paul, Beggs, Andrew, Egan, Sharon, Bessudo, Alberto, Mussai, Francis
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Case Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960181/
https://ncbi.nlm.nih.gov/pubmed/29776373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0612-6
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